FORMATION OF PICOLINIC AND QUINOLINIC ACIDS FOLLOWING ENZYMATIC OXIDATION OF 3-HYDROXYANTHRANILIC ACID

Enzymatic conversion of 3-hydroxyanthranilic acid to nicotinic acid.

The apparent conversion of tryptophan to nicotinic acid has been observed for several animal species (cf. (1)). Other studies demonstrated that at least some of the nicotinic acid (or amide) was synthesized within the tissues of the animal (2, 3). It was of interest to extend these studies and the ability of liver slices to synthesize nicotinic acid from its biologically active intermediate, 3-...

The metabolism of 3-hydroxyanthranilic and quinolinic acids in the chick embryo.

Quinolinic acid accumulation in the conversion of 3-hydroxyanthranilic acid to niacin in Neurospora.

3-Hydroxyanthranilic acid has been shown to serve as a natural precursor of niacin in Neurospora. 12 Little. information, however, has been obtained concerning the mechanism whereby the aromatic ring of 3hydroxyanthranilic acid is converted to the pyridine ring of niacin. The present paper will deal with this latter problem. Singal, et al.,I have reported that the administration of tryptophan t...

Quinolinic acid metabolism in the rat brain. Immunohistochemical identification of 3-hydroxyanthranilic acid oxygenase and quinolinic acid phosphoribosyltransferase in the hippocampal region.

Quinolinic acid (QUIN) is a potent endogenous excitotoxin, which has been shown to be present in the brain (Wolfensberger et al., 1983). In order to study the cellular localization of QUIN metabolism in the hippocampus, specific antibodies raised against purified rat liver 3-hydroxyanthranilic acid oxygenase (3HAO) and quinolinic acid phosphoribosyltransferase (QPRT), the enzymes directly respo...

Action of picolinic acid and structurally related pyridine carboxylic acids on quinolinic acid-induced cortical cholinergic damage.

Picolinic acid, a pyridine monocarboxylic acid derived from tryptophan metabolism by the kynurenine pathway, was shown to block cortical cholinergic neurotoxicity induced by quinolinic acid (QUIN), a pyridine dicarboxylic acid yielded by the same pathway. This study examined the specificity of the anti-toxic effect of picolinic acid by comparing its effect with several structurally related mono...